Effects of carbetocin, oxytocin and prostaglandin F2.ALPHA. on porcine uterine contraction in vivo.
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چکیده
منابع مشابه
Oxytocin stimulates prostaglandin F2alpha secretion and prostaglandin F synthase protein expression in porcine myometrial tissue.
The possibility of PGF(2)alpha production and presence of prostaglandin F synthase (PGFS; PGD(2) 11-ketoreductase) was studied in control and oxytocin (OT)-stimulated myometrial slices isolated from cyclic (Days 14-16) and early pregnant (Days 14-16) sows. Oxytocin (10(-7) M) stimulated (p<0.01) PGF(2)alpha production in both cycling and early pregnant myometrial slices. Prostaglandin F(2)alpha...
متن کاملEffect of LH on prostaglandin F2alpha and prostaglandin E2 secretion by cultured porcine endometrial cells.
LH appears to be a potent stimulator of the release of endometrial prostaglandins (PGs) in the pig. The aim of the present studies was to examine the effect of LH on PGF2alpha and PGE2 secretion by cultured porcine endometrial cells on days 10-12 and 14-16 of the oestrous cycle and to compare its action with oxytocin. A time-dependent effect of LH (10 ng/ml) on PGF2alpha release from luminal ep...
متن کاملOxytocin and carbetocin effects on spontaneous behavior of male rats: modulation by oxytocin receptor antagonists.
OBJECTIVES Oxytocin (OXY) in addition to peripheral actions has many central regulatory functions which can be studied on animal models. In the present study we examined in rats, which behavioral actions of OXY and long-acting carba-analog of OXY carbetocin (CBT) in the open-field can be inhibited by OXY-receptor antagonists. Our interest focused on the behavioral patterns considered indicative...
متن کاملInhibitory Effects of Two Ferulates from Angelica Sinensis on Platelet Aggregation and Oxytocin-induced Uterine Contraction
Ferulic acid (FA) is widely considered as a biologically active component in Angelica sinensis, and used as one of the marker compounds for the quality control of Angelica sinensis. However, in A. sinensis, FA mainly exists as its ester, coniferyl ferulate (CF). CF is unstable and readily hydrolyzed into FA during conventional extraction. Herein, their antiplatelet aggregation activities and re...
متن کاملEx vivo influence of carbetocin on equine myometrial muscles and comparison with oxytocin.
To determine the intercyclic effect of oxytocin and carbetocin on equine myometrial tissue, the effect of the drugs was evaluated through pharmacokinetic and pharmacodynamic studies. The complete pharmacokinetic profile for oxytocin was unknown and had to be established. To do so, 25 IU of oxytocin were administered intravenously to six cycling mares and blood samples were collected before and ...
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ژورنال
عنوان ژورنال: Nihon Yoton Gakkaishi
سال: 1990
ISSN: 1881-655X,0913-882X
DOI: 10.5938/youton.27.167